THE CONNECTION BETWEEN DIFFERENT
NEUROTRANSMITTERS INVOLVED IN COGNITIVE PROCESSES
CLAUDIA HANDRA 1, OANA ANDREIA COMAN 2, LAURENȚIU COMAN 3, TUDOR ENACHE 4, SMARANDA STOLERU 2, ADELINA-MIHAELA SORESCU 2, ISABEL GHIȚĂ 2*, ION FULGA 2
1Department of Work Medicine, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
2Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy,
Bucharest, Romania
3Department of Physiology, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
4Department of Physiology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
*corresponding author: isabelghita@yahoo.co.uk
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Abstract:
Memory is one of the most complex cognitive functions. Conventionally, one the most important neurotransmitter system
implicated in its regulation is the cholinergic system. However, literature certifies that other substances can be associated
with certain memory processes as well, for example, the dopaminergic system, the NMDA receptors and the serotoninergic
receptors, either direct, or by forming receptor complexes. Aside from these, the adrenergic system has been proven to work
synergistically with the cholinergic system. Proving the interaction between nicotine and other neurotransmitters, as well as
their involvement in cognition, opened a number of therapeutic possibilities for degenerative diseases such as Alzheimer’s
disease, Parkinson’s disease and schizophrenia. That is to say, future research needs to focus on the potential therapies using
these interactions.

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