INSIGHT INTO THE CARDIOVASCULAR ACTIVITIES OF ELAEAGNUS
UMBELLATA
RAHILA QAYYUM, HAFIZ MISBAH-UD-DIN QAMAR, UMME SALMA, SHAMIM KHAN, TAOUS KHAN, ABDUL JABBAR SHAH*
Department of Pharmacy, COMSATS Institute of Information Technology, University Road, Abbottabad-22060, KPK, Pakistan
*corresponding author: jabbarshah@ciit.net.pk
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Abstract:
This study aimed to explore pharmacological base of the medicinal use of Elaeagnus umbellata in cardiovascular diseases. In
normotensive and hypertensive rats under anaesthesia, crude extract of Elaeagnus umbellata (Eu.Cr) and selected fractions
exhibited a fall in the mean arterial pressure. In isolated rat aortic rings, crude extract and selected fractions, exhibited LNAME
sensitive endothelium dependent vasodilator effect and inhibited K+ (80 mM) pre-contractions. In isolated rabbit
aortic rings pre-constricted with K+ (80 mM) and phenylephrine (1 μM), Eu.Cr and selected fractions induced relaxation with
high potency against phenylephrine (PE). Crude extract and selected fractions had inhibitory effect on Ca2+ entry channels by
shifting Ca2+ concentration - response curves (CRCs) to the right and also suppressed phenylephrine peak formation in Ca2+-
free medium like verapamil. When tested on basal tension, the crude extract and selected fractions were devoid of any
vasoconstrictor effect. These data indicate that crude extract and selected fractions possess antihypertensive and vascular
relaxing effects.

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