SYNTHESIS, CHARACTERIZATION AND IN VITRO BIOLOGICAL
STUDIES OF NOVEL SCHIFF BASE AND ITS TRANSITION METAL
COMPLEXES DERIVED FROM SULPHADOXINE
AMINA MUMTAZ 1,2,3*, TARIQ MAHMUD 2, M.R.J. ELSEGOOD 3, G.W. WEAVER 4, JAVED IQBAL QAZI 4, FARAH DEEBA 4
1PCSIR Laboratories complex, Ferozepur Road, Lahore, Pakistan
2Institute of Chemistry, University of Punjab, Lahore 54590, Pakistan
3Departemnt of Chemistry, Loughborough University, Loughborough LE11 3TU, England, UK
4Department of Zoology, University of Punjab, Lahore, 54590, Pakistan
*corresponding author: amina.mumtaz@hotmail.com
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Abstract:
The new series of coordination transition metal complexes were preparedfrom Schiff base obtained from
sulphadoxineandthiophene-2-carboxaldehyde. The structural investigation of Schiff base and their complexes were
characterized by different instrumental procedures like microanalysis, spectroscopic andthermogravimetric examination. The
integrated Schiff base ligand and transition metal complexes were subjected to antibacterial and antifungal activities.The
studies demonstrated the enhanced activity of metal complexes against reported microbeswhen compared with free ligand.

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