OXIDATIVE STRESS PROFILE AND TYPE 2 DIABETES REMISSION
AT 6 MONTHS AFTER SLEEVE GASTRECTOMY VERSUS
CONSERVATORY TREATMENT
LIVIU IOSIF 1,2, DANIELA LIXANDRU 1*, LAURA GAMAN 1, MIHAELA ILIE 1, BOGDAN SMEU 3, DIANA SIMONA ŞTEFAN 1,4, LAURA PETCU 4, ARIANA PICU 4, ALINA CONSTANTIN 5, CONSTANTIN IONESCU-TÎRGOVIŞTE 1,4, CRISTIAN GUJA 1,4, CĂTĂLIN COPĂESCU 3, IRINA STOIAN 1,2
1“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
2R&D Irist Labmed SRL, Bucharest, Romania
3Ponderas Academic Hospital, Bucharest, Romania
4“Prof. N.C. Paulescu” National Institute of Diabetes, Nutrition and Metabolic Diseases, Bucharest, Romania
5“Nicolae Simionescu” Institute of Cellular Biology and Pathology, Bucharest, Romania
*corresponding author: daniela.lixandru@umfcd.ro
Download Full Article

Abstract:
The aim of this study was to examine the impact of weight loss on oxidant-antioxidant profile in obese T2D patients. The study was
carried out on 38 obese T2D males randomized in two groups, one that underwent laparoscopic sleeve gastrectomy (LSG) and the
other an intensive diet intervention (DTG) and standard diabetes treatment. Body mass index (BMI), fasting blood glucose, total
cholesterol, HDL-cholesterol, triglycerides, HbA1c and C Reactive Protein (CRP) were evaluated at baseline and after 6 months of
follow-up. Ghrelin, insulin, C peptide, leptin and adiponectin were also measured in all subjects by ELISA method. For oxidative
stress profile, “Respiratory Burst” and the antioxidants enzymes: paraoxonase1 (PON1), glutationperoxidase (GPx) and catalase
(CAT) were evaluated. After LSG, BMI and metabolic control improved significantly: weight loss 78.98%, fasting plasma glucose
(FPG) < 11.0 mmol/L and HbA1c < 6%. Antioxidant enzymes GPx and CAT increased after 6 months in both groups. By using
univariate conditional regression model we were able to highlight that patients with an unfavourable evolution regarding T2D
remission (HbA1c > 6%) had higher values (at baseline and after 6-months) for BMI, C peptide and CRP and lower values (at
baseline and after 6 months) for HDL and adiponectin (as an anti-inflammatory factor). We conclude that the significant weight
fluctuations can directly influence antioxidant enzyme profiles and may play an important role in the mediation of weight loss and
the beneficial metabolic effects of LSG.

Top