FENUGREEK SEED AND ITS ACTIVE AGENT DIOSGENIN
TREATMENT EFFECTS ON DIFFERENT METABOLIC
PARAMETERS IN RATS
ANDREA BADALE 1#, ANNAMARIA PALLAG 2#, MARIANN KOZMA 1, CSABA HEGEDUS 3, DIANA KOVACS 1, HAJNALKA GULYAS 1, MIHAELA ZDRINCA 4, IOAN MAGYAR 4, FELICIA MARC 4, SEBASTIAN NEMETH 2*, RITA KISS 1
1Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, 98 Nagyerdei krt., H-
4032 Debrecen, Hungary
2Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 29 Nicolae Jiga Street, R-410028
Oradea, Romania
3Cera-Med Ltd, 1 Kútvölgyi u, H-4225 Debrecen, Hungary
4Preclinical Disciplines Department, Faculty of Medicine and Pharmacy, University of Oradea, 10 1 Decembrie Square, R-
410073 Oradea, Romania
5Medical Disciplines Department, Faculty of Medicine and Pharmacy, University of Oradea, 10 1 Decembrie Square, R-
410073 Oradea, Romania
*corresponding author: sebinemeth@yahoo.com
#Authors with equal contribution
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Abstract:
In the present study we investigated the effects of chronic oral treatment with fenugreek seeds (Trigonella foenum-graecum,
TFG) and diosgenin (DG), one of its saponins, on diet induced obese (DIO) rats. Under the six weeks long treatment period
metabolic parameters such as body weight, food and water intake were daily measured. At the end of the 6 weeks we
performed insulin tolerance test (ITT). After 6 weeks of high fat diet the animals developed obesity. TFG treatment worsened
the effects of diet induced obesity on body weight, abdominal adiposity and energy intake, but it had no effect on insulin
sensitivity. Diosgenin alone did not show significant effects on the examined parameters. We conclude that diosgenin alone
did not cause any particular body weight or fat gain, but is likely to interact in a complex manner with the other ingredients of
the fenugreek seeds.

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