THE CAT AND SOD ACTIVITIES IN PATIENTS WITH CHRONIC
SUPPURATIVE OTITIS MEDIA
ROXANA ȘERBAN 1#, CODRUȚA BĂDESCU 2#, ALEXANDRU FILIP 3#*, MIHAIL DAN COBZEANU 4#, MAGDA BĂDESCU 1#, CORINA BUTNARU 4#, BOGDAN HUZUM 5#, CRISTIANA FILIP 6#
1University of Medicine and Pharmacy “Grigore T. Popa”, Faculty of Medicine, Pathophysiology Department, 16 Universității
Street, 700115, Iasi, Romania
2University of Medicine and Pharmacy “Grigore T. Popa”, Faculty of Medicine, Department of Internal Medicine, 16 Universității
Street, 700115, Iasi, Romania
3University of Medicine and Pharmacy “Grigore T. Popa”, Faculty of Medicine, Department of Orthopaedic and Traumatology,
16 Universității Street, 700115, Iasi, Romania
4University of Medicine and Pharmacy “Grigore T. Popa”, Faculty of Medicine, Otorhinolaryngology Department, 16 Universității
Street, 700115, Iasi, Romania
5University of Medicine and Pharmacy “Grigore T. Popa”, Faculty of Medicine, 16 Universității Street, 700115, Iasi, Romania
6University of Medicine and Pharmacy “Grigore T. Popa”, Faculty of Medicine, Department of Biochemistry, 16 Universității
Street, 700115, Iasi, Romania
*corresponding author: alexandru.filip@ymail.com
#All authors have equal contribution
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Abstract:
Oxidative stress plays an important role in multiple diseases by disturbing the oxidant-antioxidant balance. The aim of this
study was to evaluate the antioxidative status in patients with chronic suppurative otitis media (CSOM). We conducted a
prospective study that included 60 patients diagnosed with chronic suppurative otitis media with and without cholesteatoma.
The catalase (CAT) and superoxide dismutase (SOD) activities were determined in erythrocytes respectively serum of the
patients. We noticed that the antioxidant enzyme SOD activity in the patients with CSOM with and without cholesteatoma
had statistically significant lower values compared to the healthy subjects (p < 0.05). For the same groups the CAT activity
was statistically significant increased (p < 0.05) as compared to the healthy group. As a conclusion, oxidative stress seems to
be involved in the pathogenesis of CSOM with and without cholesteatoma, leading to chronic infections and tissue injury.






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