EFFECTS OF NICOTINIC ACID ON PROTEIN OXIDATIVE
MODIFICATIONS IN EXPERIMENTAL CHRONIC HEART FAILURE
IRYNA NIZHENKOVSKA, VIOLETTA NAROKHA *, OLENA KUZNETSOVA
Bogomolets National Medical University, Department of Pharmaceutical, Biological and Toxicological Chemistry,
Pushkinska str., 22, 01601, Kyiv, Ukraine
*corresponding author: v.narokha@ukr.net
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Abstract:
A model of chronic heart failure experimental model was induced to rats based on the toxic effects of doxorubicin. The
nature of changes in the content of protein peroxidation products (neutral and basic 2,4-dinitrophenylhydrazones) was
established in cardiomyocytes and hepatocytes of rats which received weekly intramuscular doxorubicin for 5 weeks in a
dose of 5 mg/kg body weight (bw) together with the daily intraperitoneal administration of nicotinic acid, 10 mg/kg bw. The
obtained results pointed out reduced protein peroxidation in cardiomyocytes caused by nicotinic acid, in a chronic heart
failure model in rats. This allows to consider nicotinic acid as a drug with a potential cardioprotective activity.






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