CHOLINERGIC MODULATION OF MEMORY
RALUCA ELENA MOISESCU 1#, ISABEL CRISTINA VIORICA GHIȚĂ 1#*, ADELINA SORESCU 1#, OANA ANDREIA COMAN 1#, LAURENȚIU COMAN 2#, ION FULGA 1#
“Carol Davila” University of Medicine and Pharmacy, Faculty of Medicine
1Department of Pharmacology and Pharmacotherapy
2Department of Physiology
*corresponding author: isabelghita@yahoo.co.uk
#All authors have equal contribution to this paper.
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Abstract:
Memory development is defined as the ability to encode, store and access new information. Certain neurotransmitters, but
most importantly the cholinergic transmission via nicotinic receptors, have been linked not only to memory formation but to
attention and other cognitive processes as well. In order to analyse previous literature on this subject a PubMed search was
performed and it concluded 63 articles. We determined the overall efficacy and the prevalence of specific tests used. The
implication of the cholinergic transmission via nicotinic receptors in memory has been well established over the years. Since
the evolvement of technology, the nicotinic receptors have been linked not only to normal cognitive functions, but to the
pathophysiology of certain neurodegenerative diseases as well. Due to their important roles in cognition, further studies need
to be performed in order to determine their potential therapeutic effects.

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