FLAVONOIDS AND BIOLOGICAL ACTIVITIES OF CENTAUREA
NERIMANIAE S. KULTUR
GULAY MELIKOGLU 1*, NURTEN OZSOY 2, TUGBA YILMAZ-OZDEN 2, MERYEM SEYDA ERBAY 1, SEZIN ANIL 1, BERNA OZBEK CELIK 3, SUKRAN KULTUR 4
1Department of Pharmacognosy, Faculty of Pharmacy, Istanbul University, 34116 Istanbul, Turkey
2Department of Biochemistry, Faculty of Pharmacy, Istanbul University, 34116 Istanbul, Turkey
3Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul University, 34116 Istanbul, Turkey
4Department of Pharmaceutical Botany, Faculty of Pharmacy, Istanbul University, 34116 Istanbul, Turkey
*corresponding author: gulaymelikoglu@hotmail.com
Download Full Article

Abstract:
Centaurea nerimaniae S. Kultur, an endemic species from the Turkish flora, distributed in south Anatolia (Icel Province) was
investigated for its flavonoids and in vitro antioxidant, anti-cholinergic, anti-inflammatory and antibacterial activities. The
phytochemical investigation of the plant led to the isolation of five flavonoids, identified as cirsimaritin, hispidulin, apigenin,
isokaempferide and apigenin 7-O-glucoside. In addition to its ability to inhibit AChE and lipid peroxidation, induced by
Fe3+/ascorbate system, scavenge DPPH radicals, and to reduce Fe3+ to Fe2+, the extract showed strong COX-1 and COX-2
inhibitory and antimicrobial activities, suggesting that this plant could act as an antioxidant and anti-inflammatory agent
against disorders, associated with oxidative damage, as well as an effective phytotherapeutic agent against some fungal and
bacterial diseases.

Top