AN EVALUATION OF ANTIOXIDANT, ANTIMICROBIAL,
ANTIBIOFILM AND CYTOTOXIC ACTIVITIES OF FIVE VERBASCUM
SPECIES IN TURKEY
BURCU SEN-UTSUKARCI 1*, SIBEL DOSLER 2, TURGUT TASKIN 3, MAHMOUD ABUDAYYAK 4, GUL OZHAN 5, AFIFE MAT 1
1Istanbul University, Faculty of Pharmacy, Department of Pharmacognosy, 34116, Beyazit, Istanbul, Turkey
2Istanbul University, Faculty of Pharmacy, Department of Pharmaceutical Microbiology, 34116, Beyazit, Istanbul, Turkey
3Marmara University, Faculty of Pharmacy, Department of Pharmacognosy, 34668, Haydarpasa, Istanbul, Turkey
4Karadeniz Technical University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, 61000, Trabzon, Turkey
5Istanbul University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, 34116, Beyazit, Istanbul, Turkey
*corresponding author: burcusn@gmail.com
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Abstract:
Verbascum L. species are used for different medicinal purposes in Turkish folk medicine such as diuretic, expectorant,
laxative, mucolytic, sedative, sudorific, and wound healer. Five Verbascum species, two of which are used in medicine, were
investigated for their antimicrobial, antioxidant and cytotoxic activities. Determination of the total phenolic compounds,
DPPH and ABTS methods were preferred for the antioxidant tests. The antimicrobial and antibiofilm activities of the
extracts, which were not studied previously, were investigated against pathogenic and potential pathogenic agents. The
cytotoxicity was assessed by MTT and LDH tests. This study is very important for finding new therapeutic sources and also
new, natural sources for food preservation.

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