BIOCHEMICAL DETERMINANTS OF AGGRESSIVE BEHAVIOUR –
PATHO-PHYSIOLOGICAL CONNECTIONS IN ESRDAND DIALYSIS
IRINA NEGOESCU 1#, DAN ALEXANDRU NICULESCU 2,3#, CRISTIANA DAVID 4,5#, ILEANA PERIDE 4,5*#, ANDREI NICULAE 4,5#, IONEL ALEXANDRU CHECHERIȚĂ 4,5#, CĂTĂLINA POIANĂ 2,3#
1PhD Student, “Carol Davila” University of Medicine and Pharmacy Bucharest, 37 Dionisie Lupu Street, 020021,
Bucharest, Romania
2Department of Hypophysis and Neuroendocrine Pathology, “C. I. Parhon” National Institute of Endocrinology, 34-38
Aviatorilor Boulevard, 011863, Bucharest, Romania
3Clinical Department No. 2, “Carol Davila” University of Medicine and Pharmacy Bucharest, 37 Dionisie Lupu Street,
020021, Bucharest, Romania
4Department of Nephrology and Dialysis, “Sf. Ioan” Emergency Clinical Hospital, 13 Vitan-Barzesti Road, 042122,
Bucharest, Romania
5Clinical Department No. 3, “Carol Davila” University of Medicine and Pharmacy Bucharest, 37 Dionisie Lupu Street,
020021, Bucharest, Romania
*corresponding author: ileana_peride@yahoo.com
#All authors had equal contribution to this manuscript
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Abstract:
Violence and aggression are among the most important problems of the contemporary world. Modern humanity vices, like
alcohol, drug abuse, daily stress, but also specific therapies within the positive tendency to prolong life in severe chronic diseases
seems to contribute to the ascending trend of aggressive behaviour. A topic of debate is the ability of chronic kidney disease and
its treatment to induce biochemical and behavioural changes that predispose to impulsivity. The answer can reveal treatment
adjustments (chemical, procedural and psychological) that can be made for improving behavioural condition and the quality
of life in these patients.

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