ANTI-INFLAMMATORY DRUG-LOADED BIOPOLYMERIC
SPONGIOUS MATRICES WITH THERAPEUTIC PERSPECTIVES IN
BURNS TREATMENT
DENISA IOANA UDEANU 1, MĂDĂLINA GEORGIANA ALBU KAYA 2, MIHAELA VIOLETA GHICA 3*, ȘTEFANIA MARIN 2,4, MARIA MINODORA MARIN 2,5, DURMUȘ ALPASLAN KAYA 6, LĂCRĂMIOARA POPA 3, CRISTINA DINU-PÎRVU 3
1“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Clinical Laboratory and Food
Safety, 6 Traian Vuia Street, 020956, Bucharest, Romania
2The National Research & Development Institute for Textiles and Leather, Division of Leather and Footwear Research Institute,
Department of Collagen Research, 93 Ion Minulescu Street, 031215, Bucharest, Romania
3“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Physical and Colloidal Chemistry,
6 Traian Vuia Street, 020956, Bucharest, Romania
4University Politehnica of Bucharest, Faculty of Applied Sciences, 313 Splaiul Independentei Street, 060042, Bucharest, Romania
5University Politehnica of Bucharest, Faculty of Applied Chemistry and Material Science, 1-7 Gheorghe Polizu Street, 011061,
Bucharest, Romania
6“Mustafa Kemal” University, Faculty of Agriculture, Department of Field Crops, Antakya-Hatay, 31030, Turkey
*corresponding author: mihaelaghica@yahoo.com
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Abstract:
The most important goals of burns treatment suppose a fast skin regeneration to promote healing, the initial pain reduction
and minimal scars forming. The development of new biopolymers-based wound dressings to ensure a proper healing process
is nowadays a major challenge considering the incidence and consequences of burns. Our previously designed antiinflammatory
drug-loaded biopolymeric spongious matrices were initially tested by in vitro analysis and revealed proper
morphological structure, swelling ability, degradation profiles and drug release patterns, indicating their potential use for
burns treatment. Thus, the study aims to evaluate some collagen-sodium carboxymethylcellulose spongious matrices with or
without mefenamic acid as non-steroidal anti-inflammatory drug in experimentally induced burns on Wistar rats, a frequently
used animal model for the assessment of wounds healing. The treatment with the designed sponges promoted the wound
healing compared to the classical treated control group. The sponges with mefenamic acid accelerated the healing process
with a faster epithelial regeneration and a minimal scarring in comparison with the formulations containing no antiinflammatory
drug.

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