ADRENERGIC MODULATION OF MELANOMA CELLS
PROLIFERATION
MIHAELA SURCEL 1,2, CONSTANTIN CĂRUNTU 3,4*, MIRCEA TAMPA 5, CLARA MATEI 5, SILVIU PIȚURU 5, SIMONA-ROXANA GEORGESCU 5, CAROLINA CONSTANTIN 1,7, SABINA ZURAC 6,7, MONICA NEAGU 1,2,7
1Immunology Department, "Victor Babes” National Institute of Pathology, Bucharest, Romania
2Faculty of Biology, University of Bucharest, Bucharest, Romania
3Department of Physiology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
4Department of Dermatology, “Prof. N. C. Paulescu” National Institute of Diabetes, Nutrition and Metabolic Diseases, Bucharest,
Romania
5Department of Dermatology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
6Department of Pathology, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest,
Romania
7Colentina Clinical Hospital, Bucharest, Romania
*corresponding author: costin.caruntu@gmail.com
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Abstract:
Investigation of the complex cellular and molecular mechanisms underlying cutaneous melanoma development is of major
interest in biomedical research. Within our study we have developed an in vitro experimental system using A375 human
melanoma cell line to investigate the impact of adrenergic modulation in melanoma. Thus, we have studied the proliferative
effect of norepinephrine and epinephrine in the absence and presence of several specific inhibitors. We have found that the
pro-proliferative action of norepinephrine and epinephrine can be overridden by certain inhibitors. Moreover, for some of the
inhibitors, membrane integrity hindering is associated with the actual decrease in the proliferative capacity of the tumoral
cells. Our study continues a series of experimental data that shows neurotransmitters to be involved in the proliferation of
melanoma cells and opens new research pathways for further therapeutic approaches in this field.

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