EVALUATION OF CELLULAR IMMUNE FUNCTION AND GASTRIC
TUMOUR FOR BIOMARKERS AFTER EARLY ENTERAL NUTRITION
XIANMIN BU 1#, FANGFANG XU 1#, JIE MA 2, LI WEI 1*
1Pathology Department, Jining No.1 People’s Hospital, Jining, 272111, Shandong, China
2Oncology Department, Jining No.1 People’s Hospital, Jining, 272111, Shandong, China
*corresponding author: lwrmyy@yeah.net
#Authors have equally contributed to the current paper and shared first authorship
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Abstract:
Gastric cancer has high morbidity and disability rates that influence the cellular immune function and the life quality of
patients. Surgery is the first option for the treatment of gastric cancer and in some cases, it is combined with chemotherapy
and radiotherapy. This study aimed to evaluate the role of early enteral nutrition after gastric cancer surgery on postoperative
cellular immune function and cancer biomarkers. One hundred patients with gastric carcinoma were included in the study.
Patients were divided into the experimental group A and control group B, including 50 patients per group. Group A received
early enteral nutrition treatment and group B received early parenteral nutrition treatment. The percentage of CD3+ T cells,
CD4+ T cells, CD8+ T cells, NK cells, the CD4+/CD8 + ratio and the levels of CEA, CA125, CA19-9 were measured one
day before the surgery, one day after the surgery and 14 days after the surgery in both groups. The percentage of CD3+ and
CD4+ T cells, the ratio of CD4+/CD8+ and the percentage of NK cells was decreased in group A and group B one day after
surgery compared with the levels before surgery. The decrease was significantly higher in group A compared with group B at
14 days after surgery. CEA, CA125, CA19-9 levels in both groups were decreased one day after surgery compared to the
levels before surgery and this decrease was more significant in group A compared to group B, 14 days after surgery. Early
enteral nutrition after gastric cancer surgery could effectively improve the patient's cellular immunity level and reduce the
tumour markers in gastric cancer patients.






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