ELECTROCHEMICAL SENSORS WITH PHARMACEUTICAL
APPLICATIONS BASED ON POLYMER INCLUSION MEMBRANES
CONTAINING PHOSPHOMOLYBDIC ACID COMPLEXES
MIHAI APOSTU 1, MONICA HĂNCIANU 2, GLADIOLA ȚANTARU 1, MADALINA VIERIU 1*, NELA BIBIRE 1, ALINA DIANA PANAINTE 1
”Grigore T. Popa” University of Medicine and Pharmacy Iași, Faculty of Pharmacy, 16 University Street, Iași, Romania
1Department of Analytical Chemistry
2Department of Pharmacognosy
*corresponding author: vieriu_madalina@yahoo.com
DownloadDownload Full Article

Abstract:
The article presents the construction and characterization of selective membrane sensors based on electroactive material
incorporated in PVC matrix for the determination of ranitidine, famotidine and nizatidine, which use their complexes with
phosphomolybdic acid as their electroactive material. Ion-pair complexes have been synthesized and characterized in terms
of structure, composition and solubility. The optimal proportion has been established in order to obtain homogeneous, thin,
elastic, mechanically resistant membranes and to provide the best analytical response. Optimal operating conditions have
been determined. The linear response, quantification limit, response time and selectivity were studied for each electrode. The
electrodes have been used for the potentiometric determination of H2 antihistamines from pharmaceutical products.






Top