IN VITRO CELLULAR MODELS, A RESOURCEFUL TOOL IN
RESPIRATORY TOXICOLOGY
IONEL FIZEȘAN 1, SÉBASTIEN CAMBIER 2, ELISA MOSCHINI 2, ALINE CHARY 2, ANCA POP 1*, BÉLA KISS 1, TOMMASO SERCHI 2, ARNO C. GUTLEB 2, FELICIA LOGHIN 1
1Toxicology Department, “Iuliu Hațieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, Cluj-Napoca, Romania
2Environmental Research and Innovation (ERIN) Department, Luxembourg Institute of Science and Technology, Belvaux,
Luxembourg
*corresponding author: anca.pop@umfcluj.ro
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Abstract:
Due to the increasing concerns regarding the transferability of data from animal studies to potential human health effects, the
development of complex in vitro cellular models which could potentially replace the ethically-debatable in vivo studies and
fill the existing gap between in vivo and in vitro data has received considerable attention. The current review focuses on
pulmonary in vitro cellular models available for studying the biological effects elicited by inhaled chemicals. The advantages
and disadvantages of the 2D monoculture system and the more complex 3D models such as co-cultures and organ-on-a-chip
platforms are discussed. Moreover, recent advancements in the field of respiratory toxicology such as the development of airliquid
interface systems that better mimic the in vivo respiratory exposure are reviewed. We conclude with future
perspectives of the in vitro cellular models in respiratory toxicology.

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