DNA INTERCALATING ABILITY OF FOUR ACRIDINE-N-OXYDES
DERIVATIVES INVESTIGATED BY SPECTRAL AND
ELECTROCHEMICAL TECHNIQUES
MIHAELA TERTIŞ 1, MONICA BUCŞA 2, GRAŢIELA MESEŞAN 1, ADRIAN PÎRNĂU 3, CĂLIN G. FLOARE 3, ROBERT SĂNDULESCU 1, CECILIA CRISTEA 1*
1Analytical Chemistry Department, Faculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy, 4 Louis
Pasteur Street, 400349, Cluj-Napoca, Romania
2“Raluca Ripan” Institute for Research in Chemistry, “Babeș-Bolyai” University, 30 Fântânele Street, 400294, Cluj-Napoca,
Romania
3National Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donat Street, 400293,
Cluj-Napoca, Romania
*corresponding author: ccristea@umfcluj.ro
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Abstract:
Acridines belong to one of the most frequently studied class of compounds due to their numerous physico-chemical
properties and their biological action. Thus, the use of acridines as antitumor, antibacterial, antiviral, antimalarial and antinociceptive
agents is known. Antitumour action is due to their ability to interfere with the structure of deoxyribonucleic acid
(DNA), thereby disrupting its normal functioning. Electrochemical and spectral behaviour of the four compounds were
investigated showing that only one N-oxyde acridine has the ability to intercalate into the single strand DNA (ssDNA). The
binding constant was computed using 1H-NMR.

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