SCREENING OF HETEROCYCLIC SUBSTITUTED SYDNONES FOR
POTENTIAL BIOLOGICAL ACTIVITY
NICOLETA OLGUȚA CORNELI 1, FLORIN ALBOTA 2, CRISTIANA CERASELLA DRAGOMIRESCU 1,3, MICHAELA DINA STANESCU 4*
1“Cantacuzino” National Institute of Research, 103 Splaiul Independenței, 050096, Bucharest, Romania
2“C. D. Nenițescu” Centre of Organic Chemistry, 202 Splaiul Independenței, 060021 Bucharest, Romania
3“Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 020021 Bucharest, Romania
4“C. D. Nenițescu” Department of Organic Chemistry, Faculty of Applied Chemistry and Material Science, POLITEHNICA
University, 1-7 Polizu Street, 011061, Bucharest, Romania
*corresponding author: michaela.stanescu@chimie.upb.ro
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Abstract:
Nowadays, the emergence of bacterial resistance to antibiotics has become a major public health concern; therefore the
development of new compounds overcoming the bacterial resistance is essential. Thus, this study evaluates the in vitro
antimicrobial activity of some recently synthesized sydnone derivatives, on Gram-positive (Staphylococcus aureus, Bacillus
subtilis), Gram-negative (Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa) bacteria and fungi (Candida
albicans, Aspergillus niger) and estimates the influence of sub-inhibitory concentrations of these newly synthesized
compounds on the expression of some virulence factors by bacterial strains and on adhesion ability to inert substrates.

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