ANTI-BIOFILM ACTIVITY EVALUATION AND MOLECULAR
DOCKING STUDY OF SOME 2(3-PYRIDYL)-THIAZOLYL-1,3,4-
OXADIAZOLINES
CĂTĂLIN ARANICIU 1, OVIDIU ONIGA 2, GABRIEL MARC 2*, MARIANA DOINA PALAGE 1, LUMINIȚA MĂRUȚESCU 3,4, MARIANA CARMEN CHIFIRIUC 3,4, CRISTINA IOANA STOICA 1, IOANA IONUȚ 2, SMARANDA DAFINA ONIGA 1
1“Iuliu Hațieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Therapeutic Chemistry, 12 Ion
Creangă Street, 400010, Cluj-Napoca, Romania
2“Iuliu Hațieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 41
Victor Babeș Street, 400012, Cluj-Napoca, Romania
3University of Bucharest, Faculty of Biology, Department of Microbiology, 1-3 Portocalelor Street, 60101, Bucharest, Romania
4Research Institute of the University of Bucharest – ICUB, 91-95 Independenței Street, Bucharest, Romania
*corresponding author: Marc.Gabriel@umfcluj.ro
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Abstract:
Among the most promising unconventional targets for the development of new antimicrobial drugs is bacterial adherence and
biofilm formation. This study is focused on the evaluation of a series of 2(3-pyridyl)-thiazolyl-1,3,4-oxadiazolines as
bacterial biofilm inhibitors against a panel of Gram-positive bacterial strains. Some of these compounds showed interesting
activity against biofilm formation of the Staphylococcus aureus strain. A preliminary study of the mechanism of action was
carried out by a molecular docking assay between the compounds and the Sortase A enzyme. The connection between the
docking results obtained and the anti-biofilm activity suggested that the tested compounds could have as potential mechanism
of action the inhibition of Sortase A.

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