PHYTOCHEMICAL PROFILING, ANTIOXIDANT AND CARDIOPROTECTIVE PROPERTIES OF PINOT NOIR CULTIVAR POMACE EXTRACTS
ŞTEFANIA SILVIA BALEA 1, ALINA ELENA PÂRVU 2*, NASTASIA POP 1, FERNANDO ZAMORA MARÍN 3, ANDRA ANDREICUȚ 2, MARCEL PÂRVU 4
1Department of Horticulture and Landscaping, Faculty of Horticulture, University of Agricultural Sciences and Veterinary
Medicine, 3-5 Calea Mănăştur Street, Cluj-Napoca 400372, Romania
2Department of Pathophysiology, Faculty of Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, 4-6 Victor
Babeş Street, Cluj-Napoca 400012, Romania
3Department of Biochemistry and Biotechnology, Faculty of Oenology, Rovira i Virgili University, C/Marcel.li Domingo s/n
Street, Tarragona 43007, Spain
4Department of Biology, Faculty of Biology and Geology, “Babeș-Bolyai” University, 42 Republicii Street, Cluj-Napoca
400015, Romania
*corresponding author: parvualinaelena@umfcluj.ro
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Abstract:
Fresh and fermented pomace extracts from Vitis vinifera L. Pinot noir were investigated. Total phenolic index, condensed
tannins, total anthocyanins, proanthocyanidins, flavan-3-ol monomers, stilbenes and DPPH (2,2-diphenyl-1-picrylhydrazyl)
free radical scavenger ability were measured. The effect of seven days pre-treatment on the isoprenaline-induced infarct-like
lesion in rats was assessed by monitoring ECG and serum aspartate and alanine transaminase and creatine kinase. Oxidative
stress was assessed by measuring serum total oxidative status, total antioxidant response, oxidative stress index,
malondialdehyde, total thiols and nitric oxide. The extracts had high phenolic content and antioxidant activity. Both extracts
improved ECG changes, cardiac markers and oxidative stress. In conclusions, fresh and fermented Pinot noir pomace extracts
were cardio-protective by reducing oxidative stress.

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