ANTIOXIDANT ACTIVITY EVALUATION FOR SOME NOVEL
CHROMENYL-DERIVATIVES
IOANA IONUŢ 1, DIANA OLTEANU 2*, GABRIEL MARC 1, SIMONA CLICHICI 2, DANIELA BENEDEC 3, BRÎNDUŞA TIPERCIUC 1, OVIDIU ONIGA 1
1Pharmaceutical Chemistry Department, Iuliu Haţieganu University of Medicine and Pharmacy, 41 Victor Babeş Street,
400012, Cluj-Napoca, Romania
2Physiology Department, Iuliu Haţieganu University of Medicine and Pharmacy, 1 Clinicilor Street, 400006, Cluj-Napoca,
Romania
3Pharmacognosy Department, Haţieganu University of Medicine and Pharmacy, 12 Ion Creangă Street, 400010, Cluj-
Napoca, Romania
*corresponding author: olteanu_diana_elena@yahoo.com
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Abstract:
A series of twenty previously reported compounds - chromenyl-thiosemicarbazone and chromenyl-dihydro-thiadiazole
derivatives - were screened for their in vitro antioxidant activities, using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method.
All chromenyl-thiosemicarbazones (1a-j) exhibited better DPPH scavenging activity than butylated hydroxytoluene (BHT)
and two of them (1a and 1h) were superior to ascorbic acid. Therefore, they were further investigated, on human umbilical
vein endothelial cells (HUVEC) cells, for their influence on oxidative stress, through the 2’7’-dichlorodihydrofluoresceindiacetate
(DCDHF-DA) assay. All chromenyl-thiosemicarbazones tested significantly decreased reactive oxygen species
(ROS0 production (p < 0.001, compared to the group treated only with H2O2).

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