MYCOCHEMICAL SCREENING, ANTIOXIDANT AND DNA
PROTECTING ACTIVITY OF PENICILLIUM CYCLOPIUM AND
PENICILLIUM BREVICOMPACTUM
VIOLETA D. JAKOVLJEVIĆ 1*, JASMINA М. NIKOLIĆ 1, SANJA L.J. MATIĆ 1, SNEŽANA M. STANIĆ 1, MIROSLAV M. VRVIĆ 2
1Institute for Biology and Ecology, Faculty of Science, University of Kragujevac, Radoja Domanovića 12, 34 000, Kragujevac,
Serbia
2Department of Biochemistry, Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, 11000, Belgrade, Serbia
*corresponding author: jakovljevicvioleta@gmail.com
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Abstract:
The mycochemical screening, antioxidant potential and DNA protecting potential of Penicillium cyclopium and Penicillium
brevicompactum were in the focus of this study. The ethanolic extracts of mycelia were used for the evaluation of their
antioxidant potential by the following assays: 2,2-diphenyl-1-picrylhydrazyl (DPPH) free-radical scavenging activity, total
antioxidant capacity, Fe2+-chelating activity, Fe3+-reducing capacity and DNA protection against hydroxyl radical damage.
The mycochemical analysis of the extracts revealed the presence of phenols, terpenoids, alkaloids, tannins, carbohydrates and
amino acids. The ethanolic extract of P. cyclopium contained higher amounts of phenolic compounds and ferrous ion
chelating ability. P. brevicompactum showed higher total antioxidant capacity, DPPH free-radical scavenging and reducing
power ability. Both ethanolic extracts of mycelia showed excellent ability to reduce the hydroxyl radical-induced DNA
damage. Thus, both Penicillium species can be considered as promising source of natural antioxidants.

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