COMPARATIVE DICLOFENAC DETECTION FOR CHRONIC TOXICITY
LEVELS USING WATER SOLUBLE Zn-METALLOPORPHYRIN,
GOLD NANOPARTICLES AND THEIR HYBRID
ANCA PALADE 1, ANCA LASCU 1*, IONELA FRINGU 1, LUMINITA SALAGEANU 2, DANA VLASCICI 3, MIHAELA BIRDEANU 4, EUGENIA FAGADAR-COSMA 1
1Institute of Chemistry Timisoara of Romanian Academy, M. Viteazul Ave. 24, 300223, Timișoara, Romania,
2Health Insurance House Timis, Corbului Street 4, 300239-Timișoara, Romania
3West University of Timisoara, Faculty of Chemistry-Biology-Geography, Pestalozzi Street 16, 300115, Timișoara, Romania,
4National Institute for Research and Development in Electrochemistry and Condensed Matter, 1 Plautius Andronescu Street,
300224, Timișoara, Romania
*corresponding author: ancalascu@yahoo.com
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Abstract:
The optical detection of chronic toxicity levels of diclofenac were comparatively investigated using novel nanostructured
materials, such as: a water soluble metalloporphyrin: Zn(II)-tetra-(4-N-methyl-4-pyridyl)porphyrin tetrachloride
(ZnTMePyP), tailored size spherical gold nanoparticles (n-Au) of 15 - 20 nm, and the hybrid nanomaterial (ZnTMePyP/n-
Au) formed between them. After spectroscopic and microscopic analyses, it can be stated that the water soluble Zn-porphyrin
alone can detect diclofenac in a larger domain of concentration (2.57 x 10-5 - 14.15 x 10-5 mol/L) than the hybrid formed
between the metalloporphyrin and n-Au and that the gold nanoparticles alone are not capable of diclofenac detection.






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