NEW DERIVATIVES OF 2-THIOPHENE CARBOXYLIC ACID:
SYNTHESIS, STRUCTURE AND ANTIMICROBIAL STUDIES
CARMELLINA DANIELA BĂDICEANU 1, DIANA CAMELIA NUȚĂ 1*, ALEXANDRU-VASILE MISSIR 1, MĂDĂLINA HRUBARU 2, CRISTINA DELCARU 4, LIA MARA DIȚU 3, MARIANACARMEN CHIFIRIUC 3,4, CARMEN LIMBAN 1
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6
Traian Vuia, Bucharest, 020956, Romania
2“C. D. Nenițescu” Organic Chemistry Center, Romanian Academy, 202B Splaiul Independenței, 060023, Bucharest, Romania
3Department of Microbiology-Immunology, Faculty of Biology, University of Bucharest, 1-4 Aleea Portocalelor, 60101,
Bucharest, Romania
4Research Institute of the University of Bucharest, ICUB, Earth, Environmental and Life Sciences Division University of
Bucharest, 90 Panduri Street, 060101, Bucharest, Romania
*corresponding author: diananuta@yahoo.com
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Abstract:
Thiourea and thiophene substructural units have an important significance as bioactive centres in the compounds containing
these core units, as are known to display a large spectrum of pharmacological properties. This article is focused on the
investigation of the antimicrobial activity of new thiourea and thiophene derivatives. Candidiasis, an important fungal infection,
is considered the fourth most common nosocomial blood stream infection. Nowadays, because of increased resistance to
antifungal agents, the search for new compounds has gained particular attention. Seven new thiourea derivatives having
thiophene ring, obtained from 2-thiophenecarboxilic acid, have been synthesized. The new compounds were characterized for
their physical properties (melting point, solubility), and by FT-IR and NMR spectroscopy. The antifungal activity of the
obtained compounds was assessed in vitro by qualitative and quantitative (minimum inhibitory concentration) (MIC) assays.

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