ANTIMICROBIAL PROSPECTION OF SOME COUMARIN
DERIVATIVES
GABRIELA TĂTĂRÎNGĂ 1, CRISTINA TUCHILUȘ 1*, ALEXANDRA JITĂREANU 1, ANAMARIA ZBANCIOC 1
1“Gr. T. Popa” University of Medicine and Pharmacy, Faculty of Pharmacy, Iași, Romania
2“Gr. T. Popa” University of Medicine and Pharmacy, Faculty of Medicine, Iași, Romania
*corresponding author: ctuchilus@yahoo.com
Download Full Article

Abstract:
Coumarin and their derivatives are a large chemical family which plays an important role in the field of drugs, in recent
decades a large number of studies being done on this skeleton. Despite this fact, more researches are still required in order to
synthesize and identify many other biological activities for the compounds. Twenty coumarin derivatives were synthesized in
good yields and their purity and chemical structures were elucidated by TLC, elemental analysis, IR and 1H-NMR spectra.
Their antibacterial activity against Staphylococcus aureus, Sarcina lutea, Bacillus cereus, Escherichia coli, Pseudomonas
aeruginosa and antifungal potential against Candida sp. were investigated. The results showed that all of the synthesized
compounds have exhibited significant antimicrobial activity.

Top