ANTIPROLIFERATIVE AND ANTIMICROBIAL PROPERTIES OF
PURE AND ENCAPSULATED RUTIN
CORINA DANCIU 1, IULIA ANDREEA PINZARU 2*, CRISTINA ADRIANA DEHELEAN 2, MONICA HANCIANU 3, ISTVAN ZUPKO 4, DAN NAVOLAN 5, MONICA LICKER 6, ROXANA MARIA GHIULAI 7, CODRUȚA MARINELA ŞOICA 7
1Department of Pharmacognosy, “Victor Babeş” University of Medicine and Pharmacy Timișoara, 2 Eftimie Murgu Square,
300041 Timişoara, Romania
2Department of Toxicology, “Victor Babeş” University of Medicine and Pharmacy Timișoara, 2 Eftimie Murgu Square,
300041 Timişoara, Romania
3Department of Pharmacognosy, University of Medicine and Pharmacy “Gr.T.Popa”, Faculty of Pharmacy, 16 University
Street, 700115, Iași, Romania
4Department of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös u. 6. Szeged H-6720, Hungary
5Department of Obstetrics and Gynaecology, “Victor Babeş“ University of Medicine and Pharmacy Timișoara, 2 Eftimie
Murgu Square, 300041 Timişoara, Romania
6Department of Microbiology-Virology, “Victor Babeş” University of Medicine and Pharmacy Timișoara, 2 Eftimie Murgu
Square, 300041, Timişoara, Romania
7Department of Pharmaceutical Chemistry, “Victor Babeş“ University of Medicine and Pharmacy Timișoara, 2 Eftimie
Murgu Square, 300041 Timişoara, Romania
*corresponding author: iuliapinzaru@umft.ro
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Abstract:
Rutin, a polyphenolic natural compound is described in the literature for a wide range of biological activities. The study aims
to test the antiproliferative potential and the antibacterial effect for pure rutin and its β cyclodextrin complexes. On one hand,
the antiproliferative assays against A2780 (human ovarian cells), MDA-MB-231 (human breast cancer cells) and SiHa
(cervical cancer cells) did not show any substantial inhibition of cell growth. On the other hand, the antimicrobial screening
revealed that rutin presents positive effects against: Streptococcus pyogenes, Enterococcus faecalis, Bacillus cereus, Pseudomonas
aeruginosa, Klebsiella pneumoniae and Escherichia coli. A decreased, but detectable, activity was noticed for Staphylococcus
aureus and Streptococcus pneumoniae. Incorporation in the ramified cyclodextrins had a mixed effect on the antibacterial
activity, with increased, constant or decreased effect, depending on the strain. The study concludes that rutin can be reconsiderate
as a natural active antibacterial agent, while modulation of its solubility by incorporation in β-cyclodextrins is
debatable depending on the tested strain.

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