ANTIOXIDANT, ANTIMICROBIAL AND CYTOTOXIC ACTIVITY OF
TANACETUM VULGARE, TANACETUM CORYMBOSUM AND
TANACETUM MACROPHYLLUM EXTRACTS
BIANCA IVĂNESCU 1, CRISTINA TUCHILUȘ 2*, ANDREIA CORCIOVĂ 3, CRISTINA LUNGU 1, COSMIN TEODOR MIHAI 4, ANA-MARIA GHELDIU 5, LAURIAN VLASE 5
1Department of Pharmaceutical Botany, “Gr. T. Popa” University of Medicine and Pharmacy, 16 Universității Street, Iași,
Romania
2Department of Microbiology, “Gr. T. Popa” University of Medicine and Pharmacy, 16 Universității Street, Iași, Romania
3Department of Drugs Analysis, “Gr. T. Popa” University of Medicine and Pharmacy, 16 Universității Street, Iași, Romania
4Advanced Centre for Research and Development in Experimental Medicine, “Gr. T. Popa” University of Medicine and
Pharmacy, 9 Kogălniceanu Street, Iași, Romania
5Department of Pharmaceutical Technology and Biopharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 12
Ion Creangă Street, Cluj-Napoca, Romania
*corresponding author: ctuchilus@yahoo.com
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Abstract:
The aim of this study was the evaluation of antioxidant, antimicrobial and cytotoxic activity of three Tanacetum species from
Romanian flora and the identification of biologically active compounds in the analysed species. T. vulgare and T.
corymbosum showed antioxidant activity in correlation with the total phenolic content of the extracts. All three species
exhibited antimicrobial effect against the tested Gram-positive bacteria and fungi, and manifested strong cytotoxic activity
against both cancer (HeLa) and healthy (Vero) cell lines. The chemical analyses allowed the identification of common
phytosterols and many flavonoids, some reported for the first time: casticin in T. vulgare, eupatilin, casticin, acacetin,
quercitrin and isoquercitrin in T. macrophyllum, eupatorin, apigenin and quercitrin in T. corymbosum. It is possible that the
numerous flavonoids found in these species to contribute to the pharmacological actions of the extracts.

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