CD64 EXPRESSION IN PATIENTS WITH CHRONIC PROSTATITIS
AND ITS IMPLICATION IN DIAGNOSIS
JINGHE CAO 1, BAOGANG SUN 1, YINGYING FAN 1*, ZHUANG LIU 1, NING ZHANG 1
1Reproductive Center, Affiliated Hospital of Jining Medical University, Jining, Shandong, 272029, China
*corresponding author: yingyfan2015@sina.com
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Abstract:
The aim of this study was to investigate the expression of neutrophil granulocyte cluster of differentiation 64 (CD64) in
patients with chronic prostatitis and the significance for diagnosis and treatment of chronic prostatitis. Seventy-two patients
with chronic prostatitis were selected and included in the experimental group. Moreover, thirty-five healthy individuals
represented the control group. Pathogen detection and the level of CD64 were determined in the prostatic fluids of all
individuals included in the study. Fifty-four pathogen stains were detected in the specimens of prostatic fluid of patients in
the experimental group and none in the control group. Patients infected with Staphylococcus simulans had the highest
expression level of CD64 (3912.237 ± 767.416/cell), followed by Staphylococcus auricularis (2764.371 ± 141.261/cell),
Staphylococcus warneri (1916.356 ± 127.284/cell), Enterococcus faecalis (1893.636 ± 314.458/cell) and Staphylococcus
haemolyticus (1874.328 ± 125.212/cell) the difference being significant compared to the control group (p < 0.01). There was
no significant difference between the expression levels of CD64 in control the group and in patients from the experimental
group infected with Chlamydia trachomatis, Ureaplasma urealyticum, Staphylococcus epidermidis, Staphylococcus xylosus,
Staphylococcus capitis urealyticum and Staphylococcus hominis. CD64 can be a potent marker for the diagnosis of bacteria
chronic prostatitis.

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