IN VITRO CHARACTERIZATION OF POLYVINYL ALCOHOL/
CHITOSAN HYDROGELS AS MODIFIED RELEASE SYSTEMS FOR
BISOPROLOL
ALINA-DIANA PANAINTE 1, GRAȚIELA POPA 1*, DANIELA PAMFIL 2, ELENA BUTNARU 2, CORNELIA VASILE 2, LILIANA MITITELU TARȚĂU 3, CARMEN GAFIȚANU 1
1Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 15 Universității Street, 700115, Iași,
Romania
2“Petru Poni” Institute of Macromolecular Chemistry, 41A Grigore Ghica Vodă Alley, 700487, Iași, Romania
3Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 15 Universității Street, 700115, Iași, Romania
*corresponding author: gratielapopa@yahoo.com
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Abstract:
The aim of this paper was the evaluation of bisoprolol fumarate (BF) incorporated into polyvinyl alcohol/chitosan (PVA/CS)
hydrogels and the study of its in vitro kinetic release, further used in the pharmaceutical field in oral dosage forms as
modified release systems. For all the hydrogels tested, the swelling degree decreased with the chitosan proportion increase.
Drug release was delayed and the release mechanism of the active principle was found to depend on the matrix composition.
The results obtained for these hydrogels may show interest for application in pharmaceutical and medical fields.

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