PHARMACOLOGICAL AND DISORDER ASSOCIATED
CARDIOVASCULAR CHANGES IN PATIENTS WITH PSYCHOSIS. A
COMPARISON BETWEEN OLANZAPINE AND RISPERIDONE
LIANA DEHELEAN 1#*, MINODORA ANDOR 2#, ANA MARIA ROMOŞAN 3#, MINODORA MARINELA MANEA 4#, RADU ŞTEFAN ROMOŞAN 1, ION PAPAVĂ 1, ANA CRISTINA BREDICEAN 1, VALENTINA OANA BUDA 5, MIRELA CLEOPATRA TOMESCU 2
1Psychiatry, Neurosciences Department, “Victor Babeş” University of Medicine and Pharmacy, 2 E. Murgu Square,
Timişoara, Romania
2Medical Semiology II, Internal Medicine I Department, “Victor Babeş” University of Medicine and Pharmacy, 2 E. Murgu
Square, Timişoara, Romania
3“Victor Babeş” University of Medicine and Pharmacy, 2 E. Murgu Square, Timişoara, Romania
4Psychology, Medical Education Department, “Iuliu Haţieganu” University of Medicine and Pharmacy, 8. V. Babeş Street,
Cluj-Napoca, Romania
5Pharmacology and Clinical Pharmacology, 2nd Department, “Victor Babeş” University of Medicine and Pharmacy, 2 E.
Murgu Square, Timişoara, Romania
*corresponding author: lianadeh@umft.ro
#These authors contributed equally to this work and thus share first authorship.
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Abstract:
Patients receiving antipsychotic medication present a high risk of cardiovascular complications due either to medication or to
the disorder itself. This study compares the cardiovascular risk factors and echocardiographic parameters in two samples of
outpatients with psychosis treated for at least 2 months with long acting injectable olanzapine or risperidone. We assessed the
socio-demographic data, the cardiovascular risk factors, and the echocardiographic parameters. Subjects receiving
risperidone had significantly more frequent regional myocardial contractility abnormalities (χ² = 6.896, p = 0.009) and
diastolic dysfunction of the left ventricle than those on olanzapine (χ² = 5.416, p = 0.02), and were more frequently
hypertensive. Patients with associated mood stabilizers presented more abnormalities related to the contractile function of the
left ventricle than those receiving only antipsychotic treatment (χ² = 4.138, p = 0.042). There were no differences between the
two samples concerning tobacco use or the presence of the metabolic syndrome.






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