HETEROCYCLES 42. SYNTHESIS AND CHARACTERIZATION OF
NEW THIAZOLO[3,2-B] [1,2,4]TRIAZOLE DERIVATIVES WITH
ANTI-INFLAMMATORY POTENTIAL
ANAMARIA CRISTINA 1, DENISA LEONTE 1, LAURIAN VLASE 2, LÁSZLÓ CSABA BENCZE 3, SILVIA IMRE 4, VALENTIN ZAHARIA 1*
1“Iuliu Hațieganu” University of Medicine and Pharmacy, Department of Organic Chemistry, 41 Victor Babeș Street, Ro-
400012 Cluj-Napoca, Romania
2“Iuliu Hațieganu” University of Medicine and Pharmacy, Department of Pharmaceutical Technology and Biopharmacy, 41
Victor Babeș Street, Ro-400012 Cluj-Napoca, Romania
3“Babeș-Bolyai” University, Faculty of Chemistry and Chemical Engineering, Biocatalysis and Biotransformation Research
Group, 11 Arany János Street, Ro-400028 Cluj-Napoca, Romania
4University of Medicine and Pharmacy, Department of Analitical Chemistry and Drug Analysis, 38 Gheorghe Marinescu
Street, Ro-540139 Târgu Mureș, Romania
*corresponding author: vzaharia@umfcluj.ro
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Abstract:
Heterocyclic compounds containing the 1,2,4-triazole ring and the thiazolo[3,2-b][1,2,4]triazole fused ring system in their
structure have been reported to exhibit antibacterial, antifungal, anticancer, anti-inflammatory and analgesic activities.
Considering this fact, the aim of this study was the synthesis and characterization of novel thiazolo[3,2-b][1,2,4]triazole
derivatives and their corresponding acyclic thioether intermediates, having different substituents which lead to antiinflammatory
activity. Thiazolo[3,2-b][1,2,4]triazole derivatives were obtained in a single step when the condensation
between mercapto-triazoles and α-halogenocarbonyls was performed at reflux in acid catalysis, or via acyclic thioether
intermediates, when the synthesis was performed at room temperature, in alkaline media. The synthesized compounds were
purified and characterized by 1H NMR, 13C NMR, IR and MS. Their biological potential concerning anti-inflammatory and
analgesic activities will be investigated in further studies.

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