LORATADINE-LOADED MICROEMULSIONS FOR TOPICAL
APPLICATION. FORMULATION, PHYSICOCHEMICAL
CHARACTERIZATION AND IN VITRO DRUG RELEASE EVALUATION
LAVINIA VLAIA1#, GEORGETA CONEAC1#*, IOANA OLARIU1#, ANA MARIA MUŢ1#, DAN FLORIN ANGHEL2#, MONICA ELISABETA MAXIM2#, GABRIEL ŞARAMET3#, MIRELA MITU3#, DUMITRU LUPULIASA3#, VICENŢIU VLAIA1#
1“Victor Babeş” University of Medicine and Pharmacy, Faculty of Pharmacy, 2 Eftimie Murgu Square, Timişoara, Romania
2“Ilie Murgulescu” Institute of Physical Chemistry of the Romanian Academy, Laboratory of Colloid Chemistry, 202 Splaiul
Independenţei Street, Bucharest, Romania
3“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, 6 Traian Vuia Street, Bucharest, Romania
*corresponding author: coneac.georgeta@umft.ro
#All authors have equal contribution
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Abstract:
The aim of this study was to develop and evaluate several microemulsion (ME) formulations as topical delivery systems for
loratadine (LRT), a second-generation H1 antihistaminic drug, used for allergic skin manifestations treatment. The solubility
of LRT in different oils, non-ionic surfactants and cosurfactants was determined to select the ME components. Establishment
of pseudoternary phase diagrams, using a relatively new method (Phase Diagram by Micro Plate Dilution) for several
systems, including the Captex 355/Cremophor Rh 40-Capryol 90/water system, was used to select the studied ME and gel-
ME. The selected LRT-loaded ME were characterized for physicochemical properties and in vitro drug release through
synthetic membrane. The results showed great impact of the ME components and their proportions on the mentioned
characteristics. Three of the assessed ME, presenting permeation profiles best fitted with Korsmeyer-Peppas model, were
suggested to be firstly evaluated for the in vitro drug release through a biological membrane model.

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