RELEASE STUDIES OF CEFOTAXIME SODIUM SALT FROM
COATED ION EXCHANGE RESIN MICROPARTICLES
ȘTEFANIA RACOVIȚĂ1, ION BUNIA1, IOAN PLEȘCA1, SILVIA VASILIU1, LENUȚA PROFIRE2, LILIANA FOIA2*, VASILICA TOMA2
1“Petru Poni” Institute of Macromolecular Chemistry, 41A Grigore Ghica Vodă Alley, 700487, Iași, Romania
2“Grigore T. Popa” University of Medicine and Pharmacy, 16 Universității Street, 700115, Iași, Romania
*corresponding author: lilifoia@yahoo.co.uk
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Abstract:
Microparticles based on acrylic ion exchange resin and ion exchange resins coated with two microbial exopolysaccharides
(xanthan and gellan) have been used as carriers for cefotaxime sodium salt delivery. The coated and uncoated ion exchange
resin microparticles were loaded with the drug by a diffusion process. The release kinetics of the drug was studied by elution
with solutions at different pH values. The analysis of the in vitro release data was performed using different mathematical
models such as: Boyd, Higuchi, Korsmeyer-Peppas and Baker-Lonsdale models. The kinetic data of the release process
indicates that the deliverance mechanism of cefotaxime from coated and uncoated ion exchange resin microparticles was
controlled by swelling and diffusion processes. Also, the bactericidal potential of cefotaxime released from coated and
uncoated microparticles was highlighted by antimicrobial tests.

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