ANTIMICROBIAL ACTIVITY OF SOME NEW Ru(III) COMPLEXES
WITH QUINOLONE DERIVATIVES
VALENTINA UIVAROSI1*, RODICA OLAR2, MIHAELA BADEA2, MARIANA CARMEN CHIFIRIUC3
1Department of General and Inorganic Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and
Pharmacy, 6 Traian Vuia Street, 020956, Bucharest, Romania
2Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Street, 050663,
Bucharest, Romania
3Department of Microbiology, University of Bucharest, 1-3 Portocalelor Alley, 060101, Bucharest, Romania
*corresponding author: uivarosi.valentina@umfcd.ro
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Abstract:
Two series of novel Ru(III) complexes with some quinolone derivatives previously synthesized and characterized were tested
for their antimicrobial activity. The first series consists of chelate complexes with general formula [RuL2Cl2]Cl·nH2O (L:
norfloxacin (nf), n = 4; L: ciprofloxacin (cp), n = 3; L: enrofloxacin (enro), n = 5), while the second series is represented by
complexes of general formula RuCl3L2(DMSO)m·nH2O (L: pipemidic acid (pip), m = 1, n = 2; L: enoxacin (enx), m = 1, n = 0;
L: norfloxacin (nf), m = 1, n = 1; L: ciprofloxacin, m = 2, n = 2; L: enrofloxacin (enro), m = 0.5, n = 1; L: ofloxacin (of), m = 1,
n = 1; L: levofloxacin (levof), m = 2, n = 8; DMSO: dimethylsulfoxide), The complexes were tested on Staphylococcus
aureus methicillin resistant MRSA, Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, and Bacillus subtilis
bacterial strains and their activity was expressed as inhibition of diameter growth (mm) and as minimum inhibitory
concentration, MIC (μg/mL).

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