A COMPARATIVE STUDY ON THE BIOLOGIC ACTIVITY OF
CENTAUREA CYANUS VERSUS CALENDULA OFFICINALIS
ELEONORA MARIAN1, LAURA GRAȚIELA VICAȘ1, JURCA TUNDE1, MARIANA MUREȘAN2, ROXANA LIANA STAN3*, BOGDAN SEVASTRE4, ZORIȚA DIACONEASA4, CORINA IONESCU3, ADRIANA CORINA HANGAN5
1University of Oradea, Medicine and Pharmacy Faculty, Department of Pharmacy, 29 Nicolae Jiga Street, 410028, Oradea,
Romania
2University of Oradea, Medicine and Pharmacy Faculty, Department of Preclinical Sciences, 10 1st December Square, 410068,
Oradea, Romania
3“Iuliu Hațieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biochemistry
and Clinical Laboratory, 6 Pasteur Street, 400012, Cluj-Napoca, Romania
4University of Agricultural Science and Veterinary Medicine, Faculty of Veterinary Medicine, Paraclinic/Clinic Department,
3-5 Calea Mănăștur Street, 400372, Cluj-Napoca, Romania
5“Iuliu Hațieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Inorganic Chemistry, 12 Ion
Creangă Street, 400010, Cluj-Napoca, Romania
*corresponding author: roxanaluc@yahoo.com
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Abstract:
Considering that the therapeutic activity of Centaurea cyanus is less known, in the present study we aimed to evaluate its
biological activity compared to Calendula officinalis. The alcoholic extracts from the two vegetal products were evaluated in
terms of chemical composition, the concentrations being expressed in total polyphenols (gallic acid) and total flavonoids
(quercetin). The studies carried out have shown the protective effect of the plant extracts against free radicals (superoxide
dismutase - SOD-like activity in vivo), their antioxidant capacity (DPPH, FRAP, CUPRAC methods) and cytotoxicity assays.
Centaurea cyanus possesses superior biological activities versus Calendula officinalis.

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