DESIGN AND EVALUATION OF A TRANSDERMAL PATCH WITH
ATORVASTATIN
PABLO SERRANO CASTAÑEDA1,2, JOSÉ JUAN ESCOBAR-CHÁVEZ1*, ABRAHAM TORRES AGUADO1, ISABEL MARLEN RODRÍGUEZ CRUZ3, LUZ MARÍA MELGOZA CONTRERAS2
1School of Advanced Studies Cuautitlan – National Autonomous University of Mexico, Multidisciplinary Research Unit,
Laboratory 12: Transdermal Systems, Cuautitlan Teoloyucan road, km 2.5 San Sebastian Xhala C.P 54714 Cuautitlan
Izcalli, State of Mexico, Mexico
2Autonomous Metropolitan University – Xochimilco – Department of Biological Systems, Calzada del Hueso 1100. Colonia Villa
Quietud. C.P. 04960. Mexico City
3Regional Hospital of High Specialty of Zumpango. Teaching and Research Unit. Zumpango, State of Mexico. Zumpango-
Jilotzingo Highway #400, Barrio de Santiago 2nd Section, Zumpango, State of Mexico, C.P. 55600
*corresponding author: josejuanescobar@gmail.com
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Abstract:
A transdermal patch loaded with atorvastatin was developed in order to improve dyslipidaemia therapy and had good drug
release for several days. This transdermal system can be used as a new alternative for the treatment of hypercholesterolemia.
Transdermal patches (TP) were generated by the plate casting technique; the evaluated patches were generated using a
factorial design to obtain the optimum formulation. The patches were characterized by differential scanning calorimetry
(DSC), scanning electron microscopy (SEM), bioadhesion, post-wetting-bioadhesion, tensile strength, drug release studies
and in vitro percutaneous absorption studies. The results obtained for optimal TP formulation showed good properties such as
no interactions between drug and excipients in DSC studies, 1063.05 gf of bioadhesion and 995.9 gf for post-wettingbioadhesion,
the tensile strength of 1307.5 gf, thickness of 0.43 mm, the SEM studies showed a porous matrix with no
precipitates of the drug, good drug release adjusted to Higuchi model and a flux of atorvastatin of 8.6 μg/cm2/h for
percutaneous in vitro absorption. The optimal TP proved the release of atorvastatin during several days.






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