IN VITRO ASSESSMENTS OF POTENTIAL TOPICAL APPLICATION
FOR ORGANOMETALLIC COMPLEXES OF COPPER WITH
OXICAMS
CONSTANTIN-PETRU TUDOSĂ1, DUMITRU LUPULIASA2, SULTANA NIȚĂ3, MIRELA ADRIANA MITU2*, LUCIAN HÎNCU1, FLAVIAN ȘTEFAN RĂDULESCU1, DALIA SIMONA MIRON4
1Department of Drug Industry and Pharmaceutical Biotechnologies, Faculty of Pharmacy, “Carol Davila” University of
Medicine and Pharmacy Bucharest, 6 Traian Vuia Street, 020956, Bucharest, Romania
2Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, “Carol Davila” University of
Medicine and Pharmacy Bucharest, 6 Traian Vuia Street, 020956, Bucharest, Romania
3National Institute for Chemical Pharmaceutical Research and Development, 112 Calea Vitan Street, Bucharest, Romania
4Department of Pharmaceutical Physics and Informatics, Faculty of Pharmacy, “Carol Davila” University of Medicine and
Pharmacy Bucharest, 6 Traian Vuia Street, 020956, Bucharest, Romania
*corresponding author: mitumirela@gmail.com
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Abstract:
The paper presents the assessment of the solubility, distribution coefficient and in vitro release from liquid and semisolid
vehicles for organometallic complexes of copper with oxicam ligands. Aqueous buffers systems with physiological pH and
biorelevant organic solvents such as n-octanol and isopropyl-myristate were used in developing simple experimental
procedures. The substances were described as model entities for increased hydrophobicity and the results were discussed in
terms of the utility and limitations of these methodologies for screening the feasibility of delivery across the skin.

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