A NEW ESCULETIN GLYCOSIDE FROM CALENDULA OFFICINALIS
(ASTERACEAE) AND ITS BIOACTIVITY
DANIIL N. OLENNIKOV1*, NINA I. KASHCHENKO1, CECILE VENNOS2
1Institute of General and Experimental Biology, Siberian Division, Russian Academy of Science, Sakh’yanovoy Str., 6, Ulan-
Ude, Russia
2Regulatory and Medical Scientific Affairs, Padma AG, Underfeldstrasse 1, CH-8340, Hinwil, 670047, Switzerland
*corresponding author: olennikovdn@mail.ru
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Abstract:
A new coumarin glycoside, neoisobaisseoside, was isolated from the flowers of Calendula officinalis L. (Asteraceae),
together with three known compounds identified as isobaisseoside, haploperoside A and haploperoside D. The structure of
neoisobaisseoside was characterized as 6,7-dihydroxycoumarin-7-О-(2′-О-α-l-rhamnopyranosyl)-β-d-glycopyranoside or
esculetin-7-O-neohesperiodoside, based on UV-, NMR-spectroscopy and mass-spectrometric data. Investigation of the
biological properties of neoisobaisseoside demonstrated its amylase and α-glucosidase inhibiting activity as well as its ability
to reduce the production of advanced glycation end-products formed in the Maillard reaction. These facts indicate that
neoisobaisseoside could be a potential anti-diabetic agent.






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