STUDY DESCRIBING THE FORMULATION AND THE RELEASE OF
SOME ACTIVE PHARMACEUTICAL INGREDIENTS FROM HPMC
HYDROPHILIC MATRIX TABLETS. NOTE I
GABRIEL ȘARAMET1#, FLAVIAN ȘTEFAN RĂDULESCU2#, DALIA SIMONA MIRON3#, ȘTEFANIA-FELICIA BĂRBUCEANU4#, ANA ANDREEA STĂNESCU1#*, LAVINIA VLAIA5#, SILVIU PIȚURU6#, DUMITRU LUPULIASA1#
1“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Technology
and Biopharmacy, Bucharest, Romania
2“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Drug Industry and
Pharmaceutical Biotechnologies, Bucharest, Romania
3“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Pharmaceutical Physics and Informatics,
Bucharest, Romania
4“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Organic Chemistry, Bucharest,
Romania
5“Victor Babeș” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Technology,
Timișoara, Romania
6“Carol Davila” University of Medicine and Pharmacy Bucharest, 37th Dionisie Lupu Street, 020022, Bucharest, Romania
*corresponding author: aastanescu@gmail.com
#All authors have equally contributed to the current paper.
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Abstract:
For this study, hydroxypropylmethylcellulose (HPMC) matrix tablets were prepared by direct compression containing active
pharmaceutical ingredients (APIs) from different biopharmaceutical classification system (BCS) classes, diclofenacum
sodium (DicloNa) and phenytoin sodium (PheNa). For each API, three formulations were obtained, varying the amount of
API and the concentration of HPMC matrix. After preparation, the tablets were submitted to pharmaco-technical tests and
dissolution tests. The dissolution data was then fitted on different release models. Informations about the release kinetics
from our tablets were obtained from these fittings.

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