POTENTIAL PHARMACEUTICAL USES OF PROBIOTICS AND
PREBIOTICS IN OBESITY MANAGEMENT
ADELA CARAMOCI1*, MIRELA VASILESCU2, ADRIANA SARAH NICA3, MIRELA POP4, EUGENIA ROSULESCU2, ANCA MIRELA IONESCU1
1Departament of Sports Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
2Department of Kinetotherapy and Sports Medicine, University of Craiova, Romania
3Departament of Rehabilitation, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
4Mirmed-Aslan Clinic, Bucharest, Romania
*corresponding author: adelaapostol@yahoo.com
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Abstract:
Although the pathophysiology of obesity is multifactorial, many recent studies have suggested that it implies an alteration of
gut microbiota. The mechanisms by which dysbiosis contributes to obesity are numerous and include an increased energy
harvest, alteration of intestinal barrier, systemic inflammation and hormonal imbalance. The therapeutic interventions for the
improvement of intestinal microflora may promote weight loss and prevent weight gain. Probiotics and prebiotics have been
proposed as practical and affordable solutions for reaching this goal. This paper, by reviewing the scientific literature, intends
to clarify whether and in what conditions these agents can be used in the management of obesity.

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