DETERMINATION OF IBUPROFEN BASED ON SCREEN-PRINTED
ELECTRODES MODIFIED WITH CARBON NANOFIBERS
IRINA MIRELA APETREI1, ADRIANA AURORA BEJINARU2, MONICA BOEV1, CONSTANTIN APETREI3*, OLIMPIA DUMITRIU BUZIA1
1Department of Pharmaceutical Sciences, Medical and Pharmaceutical Research Centre, Faculty of Medicine and
Pharmacy, “Dunărea de Jos” University of Galați, Romania
2Department of Dental Medicine, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University of Galați, Romania
3Department of Chemistry, Physics and Environment, “Dunărea de Jos” University of Galați, Romania
*corresponding author: apetreic@ugal.ro
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Abstract:
Electrochemical determination of ibuprofen has been employed by cyclic voltammetry and differential pulse voltammetry,
using a screen-printed carbon electrode modified with carbon nanofibers. The mechanism of the oxidation process for
ibuprofen is controlled by diffusion. A well-defined anodic oxidation peak has been obtained at + 1.08 V vs. Ag in 0.2 M
acetate buffer (pH 4.5). The quantitative determination of ibuprofen has been conducted in optimal experimental conditions
by differential pulse voltammetry, in the linear range between 8 × 10-7 M and 3 × 10-5 M and a detection limit of 3.5 × 10-7 M
was established. The sensor has shown stability and good reproducible voltammetric response, which recommends its use in
the analysis of pharmaceutical products. The quantity of ibuprofen acquired in the analysis of pharmaceutical products is
compliant with the quantities obtained by using the usual methods.

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