SYNERGIC BENEFITS OF ARONIA MELANOCARPA ANTHOCYANIN –
RICH EXTRACTS AND ANTIBIOTICS USED FOR URINARY TRACT
INFECTIONS
REMO DORNEANU1, OANA CIOANCĂ1*, OANA CHIFIRIUC2, ELENA ALBU1, CRISTINA TUCHILUŞ1, CORNELIA MIRCEA1, IVAN SALAMON3, MONICA HĂNCIANU1
1“Gr. T. Popa” University of Medicine and Pharmacy, 16 Universității Street, Iași, Romania
2Research Institute of the University of Bucharest, Bucharest, Romania
3University of Presov, 15 17th November Street, Presov, Slovak Republic
*corresponding author: oana.cioanca@gmail.com
Download Full Article

Abstract:
Anthocyanins are well known for their powerful antioxidative potential, however new insights are discovered every year
regarding their health benefits. For the present study, we investigated several anthocyanin-rich extracts in terms of their
antimicrobial synergistic effect with commonly used antibiotics in urinary tract infections (UTI). The selected samples,
lyophilized powders from Aronia melanocarpa L., were obtained from mature fruits cultivated in ecological environment in
the Eastern Carpathians in Romania. The optimized extracts were obtained by selective liquid-liquid extraction in ethanol and
acetone and then submitted to analysis. The chemical profile of the polyphenols was established by spectrophotometric and
ultra-performance liquid chromatography (UPLC) techniques. To further confirm the value of the extracts we submitted them
to some antioxidant tests: 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS·+) radical cation scavenging assay
and lipoxygenase inhibition test. The minimal inhibitory concentration (MIC) and minimal biofilm eradication concentration
(MBEC) of the extracts against several standard and clinical isolated Gram-positive and Gram-negative strains were
determined. Our results indicated that the differences induced by the type of solvent used for extraction has a significant
impact on the biological activity intensity of each sample.

Top