BIOAVAILABILITY OF VALPROATE SUPPOSITORIES
FORMULATED FOR PAEDIATRIC USE
NICOLETA TODORAN1, ADRIANA CIURBA1*, SZENDE VANCEA2, CAMIL-EUGEN VARI3, MARIA-TITICA DOGARU3, ALEXANDRINA TĂUREAN4, DANIELA-LUCIA MUNTEAN5, ROBERT-ALEXANDRU VLAD1, FELICIA GLIGOR6
1University of Medicine and Pharmacy of Tîrgu Mureş, Faculty of Pharmacy, Department of Pharmaceutical Technology, 38
Gh. Marinescu Street, 540139, Târgu Mureș, Romania
2University of Medicine and Pharmacy of Tîrgu Mureş, Faculty of Pharmacy, Department of Physical Chemistry, 38 Gh.
Marinescu Street, 540139, Târgu Mureș, Romania
3University of Medicine and Pharmacy of Tîrgu Mureş, Faculty of Pharmacy, Department of Pharmacology and Clinical
Pharmacy, 38 Gh. Marinescu Street, 540139, Târgu Mureș, Romania
4Pharmacy no.3, Emergency Clinical County Hospital of Târgu Mureș, 50 Gh. Marinescu Street, 540136, Târgu Mureș,
Romania
5University of Medicine and Pharmacy of Tîrgu Mureş, Faculty of Pharmacy, Department of Analytical Chemistry and
Analysis of Medicine, 38 Gh. Marinescu Street, 540139, Târgu Mureș, Romania
6“Lucian Blaga” University, Faculty of Medicine, Department of Biochemistry, 10 Victoriei Blvd., 550024, Sibiu, Romania
*corresponding author: adriana.ciurba@umftgm.ro
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Abstract:
Considering that the rectal route might eliminate the time-dependent changes of valproic acid kinetics and starting from the
need to develop suppositories for paediatric use, in our previous studies three types of valproate suppositories were selected
for further in vivo investigation. In this paper, the experimental pharmacokinetic study conducted on rabbits is presented, in
order to evaluate the relevant in vivo pharmacokinetic parameters. The parameters obtained after a single rectal dose over a
period of 8 h, were analysed in each case by the non-compartmental pharmacokinetic model. The similarity of the three
release profiles previously found in vitro has not fully confirmed the in vivo parameters, which shows that the in vivo
pharmacokinetic test still remains necessary in case of studies on the development of suppositories formulation.






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