ANTI α-GLUCOSIDASE, ANTITUMOUR, ANTIOXIDATIVE,
ANTIMICROBIAL ACTIVITY, NUTRITIVE AND HEALTH
PROTECTIVE POTENTIAL OF SOME SEAWEEDS FROM THE
ADRIATIC COAST OF MONTENEGRO
SANJA MILOVIĆ1, TATJANA KUNDAKOVIĆ1, VESNA MAČIĆ2, JELENA ANTIĆ STANKOVIĆ1, NAĐA GROZDANIĆ3, IVANA ĐURIČIĆ1, IVAN STANKOVIĆ1, TATJANA STANOJKOVIĆ3*
1Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia
2Institute of Marine Biology, P.O. Box 69, 85330 Kotor, Montenegro
3Institute of Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Serbia
*corresponding author: tanjast@lycos.com
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Abstract:
The aim of the present study was to reveal the potential biological activities of the dichlorometane:methanol (1:1) dry extract
(DME) and the nutritional value of selected seaweeds: Cymodocea nodosa, Halimeda tuna, Cystoseira barbata and Codium
bursa, collected from the Adriatic coast, Montenegro. We assessed the chemical composition and several biological activities
such as: anti- α-glucosidase, antitumour, antimicrobial and antioxidative activity. H. tuna had the best cytotoxic activity
against human colon carcinoma cell line, LS174 (IC50 = 17.92 ± 1.54 μg/mL). C. nodosa demonstrated strong cytotoxicity
against human adenocarcinoma cell line, HeLa (IC50 = 13.28 ± 0.39 μg/mL) and human chronic myelogenous leukaemia cell
line, K562 (IC50 = 19.64 ± 1.55 μg/mL). C. barbata had the best anti α-glucosidase (IC50 = 9.98 ± 3.34 μg/mL) and
antimicrobial activity (minimal inhibitory concentration of 100 μg/mL) for Staphylococcus aureus and Bacillus subtilis. C.
bursa showed the highest nutritional value (490.4 kcal).

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