Fe3O4/SALICYLIC ACID MAGNETIC NANOPARTICLES DELIVERY
ROUTE. A SIMPLE METHOD FOR TISSUE TARGETING
ADELA-LUIZA CHIRILĂ1, ION MÎNDRILĂ1*, DAN EDUARD MIHAIESCU2, BOGDAN MÎNDRILĂ1, CRISTINA PREDOI1, OVIDIU MARCEL MĂRGINEAN1, IONICA PIRICI1, GABRIELA RĂU3, ALICE SANDRA BUTEICĂ3
1Morphological Sciences Department, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Craiova,
Romania
2“Costin Nenițescu” Department of Organic Chemistry, Faculty of Applied Chemistry and Materials Science, Politehnica
University of Bucharest, Bucharest, Romania
3Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania
*corresponding author: tutu0101@yahoo.com
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Abstract:
Administration routes can greatly influence the pharmacokinetics, biodistribution and toxicity profile of the iron oxide
nanoparticles. The purpose of this study was to investigate on a rat model the effect of three main administration routes of an
aqueous dispersion of Fe3O4/salicylic acid magnetic nanoparticles (SaMNPs) on the pattern of their intravisceral storage. In
order to identify the SaMNPs aggregates in the viscera we used Perl’s Prussian blue stain. Specific tissue or cell targeting for
SaMNPs deposits can be obtained by either of the three delivery systems employed in our study. The aerosol-mediated
delivery is recommended for pulmonary and cardiac tissues targeting, the intravenous route is preferable for hepatic and renal
tissues targeting and the intragastric administration is the recommended route for SaMNPs delivery to the hepatic, renal and
cardiac tissues.

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