BIOLOGICAL EVALUATION OF CHITOSAN-ANTIDIABETIC DRUG
FORMULATIONS FOR THE TREATMENT OF DIABETES MELLITUS
FLORENTINA GIANINA LUPAŞCU1, IUSTINA AVRAM1, LUMINIŢA CONFEDERAT1, SANDRA MĂDĂLINA CONSTANTIN1, CRISTINEL IONEL STAN2*, ELENA CĂTĂLINA LUPUŞORU3, ALEXANDRU SAVA1, LENUŢA PROFIRE1
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy,
16 Universităţii Street, 700115, Iaşi, Romania
2Department of Morphofunctional Science I, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy,
16 Universităţii Street, 700115, Iaşi, Romania
3Department of Morphofunctional Science II, Faculty of Medicine, “Grigore T. Popa” University of Medicine and
Pharmacy, 16 Universităţii Street, 700115, Iaşi, Romania
*corresponding author: cristi_stan00@yahoo.com
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Abstract:
The aim of this study was to investigate the biological effects of some chitosan-antidiabetic drug formulations on diabetes
mellitus induced with streptozotocin to rats. The biochemical parameters such as glycaemia, glycosylated haemoglobin and
hepatic, renal and lipid metabolism parameters were investigated. The food and water intake and body weight were also
monitored as clinical parameters. The results showed that chitosan-antidiabetic drug formulations (chitosan-metformin: CSM,
chitosan-glibenclamide: CS-G, chitosan-metformin-glibenclamide: CS-MG) improved the biochemical and clinical
parameters of diabetic rats which shows the beneficial effects of chitosan for diabetes mellitus treatment. The best results
were obtained with CS-MG for which there were recorded the best hypoglycaemic effect in comparison with CS-M and CSG.
This polymeric system also showed good values for blood glycosylated haemoglobin (HbA1c), biochemical liver and
renal function parameters: ALT, AST, LDH, total bilirubin, direct bilirubin and urea, creatinine and uric acid respectively.

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