SYNTHESIS AND ANTIMICROBIAL ACTIVITY EVALUATION OF
SOME NEW 2-(3-PYRIDIL)-THIAZOLYL-1,3,4-OXADIAZOLINES
SMARANDA DAFINA ONIGA1, CĂTĂLIN ARANICIU1*, CRISTINA IOANA STOICA1, MARIANA DOINA PALAGE1, LAURIAN VLASE2, ADRIAN PIRNAU3, LUMINIȚA MARUȚESCU4,5, MARIANA CARMEN CHIFIRIUC4,5, OVIDIU ONIGA6
1“Iuliu Hațieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Therapeutic Chemistry, 12
Ion Creangă Street, 400010, Cluj-Napoca, Romania
2“Iuliu Hațieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Technology
and Biopharmacy, 41 Victor Babeș Street, 400012, Cluj-Napoca, Romania
3National Institute for Research and Development of Isotopic and Molecular Technologies, 65-103 Donat Street, 400293,
Cluj-Napoca, Romania
4University of Bucharest, Faculty of Biology, Department of Microbiology, 1-3 Portocalelor Street, 60101, Bucharest,
Romania
5Research Institute of the University of Bucharest - ICUB, 91-95 Independenței Street, Bucharest, Romania
6“Iuliu Hațieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Chemistry,
41 Victor Babeș Street, 400012, Cluj-Napoca, Romania
*corresponding author: araniciu.catalin@umfcluj.ro
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Abstract:
A new series of 4-methyl-2-(pyridin-3-yl)-thiazole-5-yl-oxadiazolines were synthesized starting from 4-methyl-2-(pyridin-3-
yl)thiazole-5-carbohydrazide. The newly synthesized compounds were characterized by analytical 1H-NMR, 13C-NMR and
mass spectral data. These compounds were screened for their antimicrobial activity against Gram-positive and Gram-negative
bacterial strains and one fungal strain (Candida albicans).

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