INVESTIGATION OF ANTIOXIDANT AND ANTIMICROBIAL
POTENTIAL OF SOME EXTRACTS FROM HEDERA HELIX L.
CARMEN ELENA POP1#, MARCEL PÂRVU2#, ANDREEA LETIȚIA ARSENE3#*, ALINA ELENA PÂRVU4#, DAN CRISTIAN VODNAR5#, MONICA TARCEA6#, ANCA MARIA TOIU7#, LAURIAN VLASE8#
1“Iuliu Haţieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Drug Industry and
Pharmaceutical Biotechnology, 8 Victor Babeș Street, Cluj-Napoca, Romania
2“Babeș - Bolyai” University, Faculty of Biology and Geology, Department of Biology, 42 Republicii Street, Cluj-Napoca,
Romania
3“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of General and Pharmaceutical
Microbiology, 6 Traian Vuia Street, District 2, Bucharest, Romania
4“Iuliu Hațieganu” University of Medicine and Pharmacy, Faculty of Medicine, Department of Pathophysiology, 3 Victor
Babeș Street, Cluj-Napoca, Romania
5University of Agricultural Sciences and Veterinary Medicine, Faculty of Food Science and Technology, Department of Food
Science, 3-5 Mănăștur Street, Cluj-Napoca, Romania
6University of Medicine and Pharmacy, Faculty of Medicine, Department of Community Nutrition and Food Safety, 38
Gheorghe Marinescu Street, Târgu Mureș, Romania
7“Iuliu Hațieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacognosy, 8 Victor
Babeș Street, Cluj-Napoca, Romania
8“Iuliu Hațieganu” University of Medicine and Pharmacy, Department of Pharmaceutical Technology and
Biopharmaceutics, 8 Victor Babeș Street, Cluj-Napoca, Romania
*corresponding author: andreeanitulescu@hotmail.com
#All authors have equal contribution to this paper.
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Abstract:
The aim of this study was the investigation of the antioxidant and the antimicrobial potential of some ethanolic extracts from
Hedera helix (leaves, flowers, immature and ripe fruits) and the correlation with the profile of polyphenols, using an LC/MS
method. In all samples, the chlorogenic acid, isoquercitrin, rutin and quercetin have been identified. The DPPH (2,2-
diphenyl-1-picrylhydrazyl) assay, Total Phenolic Content (TPC) and Total Flavonoid Content (TFC) were used to evaluate
the antioxidant effects and the results showed a better antioxidant activity for H. helix ripe fruits ethanolic extract and a
positive correlation between antioxidant effects, polyphenolic and flavonoid contents. The antimicrobial effect was tested
using six bacterial strains and the microdilution method. The immature fruits extract showed a significant antibacterial
activity against Staphylococcus aureus, while both immature fruits and flowers extracts possess a good antibacterial activity
against Listeria monocytogenes.

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