PHARMACOKINETIC CHARACTERISTICS OF VANCOMYCIN IN
THE TREATMENT OF CRITICALLY ILL PATIENTS WITH
PULMONARY INFECTIONS
QINGXIA ZHENG1, LIPING LIU1, XIAOWEI MA1, RUI YANG1*
1Critical Care Medicine, Hongqi Hospital of Mudanjiang Medical University, MuDanjiang City, 157011, China
*corresponding author: dr_yangrui@yahoo.com
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Abstract:
The aim of this study was to analyse the pharmacokinetics of vancomycin in the anti-infective treatment of critically ill
patients from Intensive Care Unit (ICU) with pulmonary infections. The ICU patients were divided according to endogenous
creatinine clearance rate (CLCR) into two groups: the normal renal function group (CLCR > 90 mL/min, n = 10) and the renal
dysfunction group (CLCR < 90mL/min, n = 10). The endogenous creatinine clearance rate (CLCR) was calculated by
determining the serum creatinine. The liver and kidney function, circulatory system function, infection index, age and body
weights of patients were analysed. The pharmacokinetic parameters were calculated using DAS2.0 software. The
pharmacokinetic parameters obtained were t1/2α = 0.38 h, Vd = 0.41 L/kg, t1/2β = 9.81 h, CL = 0.059 L/min, the peak
concentration of treatment was 42.69 mg/L, and the lowest concentration was 11.97 mg/L. The pharmacokinetic parameters
of the normal renal function group were t1/2α = 0.26 h, t1/2β = 7.68 h, Vd = 0.28 L/kg, CL = 0.065 L/min. The pharmacokinetic
parameters of the renal dysfunction group were t1/2α = 0.43 h, t1/2β = 11.41 h, Vd = 0.42 L/kg, CL = 0.058 L/min. Creatinine
clearance showed that the initial dose of vancomycin administered to the patients could not reach the treatment goal, so a new
dose is needed to be administered in order to improve the treatment compliance. ICU patients have high drug metabolism and
high circulating dynamic state, the age and renal function being the main factors that influence the drug metabolism.

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