THE INFLUENCE OF A NEW RUTIN DERIVATIVE IN AN EXPERIMENTAL MODEL OF INDUCED HYPERHOMOCYSTEINEMIA IN RATS
CRISTIANA FILIP1, ELENA ALBU2*, DAN LUPAȘCU3, NINA FILIP1
“Grigore T. Popa” University of Medicine and Pharmacy, Iași, Romania
1Department of Biochemistry,
2Department of Pharmacology,
3Department of Pharmaceutical Chemistry
*corresponding author: elenaalbu@yahoo.com
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Abstract:
Cardiovascular diseases are a major cause of deaths today. It is generally accepted the involvement of three major risk
factors: hyperlipidaemia, hyperhomocysteinemia and the molecular reactive species excess. Therapeutic approaches try to
reduce the levels of lipids and homocysteine and to keep the balance between the oxidation/reduction system. We studied a
new rutin derivative coded L103 that may determine the lowering of the lipid level and antioxidant properties. L103 contains
a pyridine group attached to a rutin molecule. We studied the influence of L103 on the plasmatic levels of cholesterol, total
antioxidant status and homocysteine in hyperhomocysteinemia experimentally induced in a rat model through methionine
loading. The obtained data suggest that L103 succeeds to prevent the decline of the total antioxidant status, keeps cholesterol
within normal ranges but has minor effects on the homocysteine levels. Despite the low influence on homocysteine, L103
confers protection against two of the major risk factors incriminated in cardiovascular diseases.

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